2011    The Ernst Jung Medical Award, Germany 9 Hubrecht Organoid Technology, Utrecht, The Netherlands. 2019    Keio Medical Science Prize of the Keio University (Japan) The Clevers group studies the biology of Wnt signaling in tissue turnover and in cancer. Present members are: Prof. Dr. Christine Mummery, Leiden University Medical Center, Leiden (chair) For example, during the last year more than half of the top publications from the Hubrecht Institute involved more than two Hubrecht groups, demonstrating the collaborative spirit. The Clevers group studies the molecular mechanisms of tissue development and cancer of various organs using organoids made from adult Lgr5 stem cells. Nature 476: 293-297 (2011), 34)           Li, V.S., Ng, S.S., Boersema, P.J., Low, T.Y., Karthaus, W.R., Gerlach, J.P., Mohammed, S., Heck, A.J., Maurice, M.M., Mahmoudi, T. and Clevers H. Wnt signaling inhibits proteasomal β-catenin degradation within a compositionally intact Axin1 complex. Science 327: 1385-1389 (2010), 30)           Sato, T., van Es, J.H., Snippert, H.J., Stange, D.E., Vries, R.G., van den Born, M., Barker, N., Shroyer, N.F., van de Wetering, M., Clevers, H. Paneth cells constitute the niche for Lgr5 stem cells in intestinal crypts. 2 Oncode Institute, Hubrecht Institute, Royal Netherlands Academy of Arts and Sciences and University Medical Centre Utrecht, Utrecht, Netherlands. Cell 155: 357-368 (2013), 43)           Schwank, G., Koo, B.K., Sasselli, V., Dekkers, J.F., Heo, I., Demircan, T., Sasaki, N., Boymans, S., Cuppen, E., van der Ent, C.K., Nieuwenhuis, E.E., Beekman, J.M., Clevers, H. Functional Repair of CFTR by CRISPR/Cas9 in Intestinal Stem Cell Organoids of Cystic Fibrosis Patients. The Hubrecht Institute has a tight collaboration with the UU on multiple levels: there is a lot of scientific collaboration, several PI’s are appointed as professor at the UU, all Hubrecht PhD students participate in the Graduate School of Life Sciences and various Master students perform their internships at one of the Hubrecht groups. 3584 CT Utrecht The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), situated on the Utrecht Science Park. 2015 – present  Member of the Scientific Advisory Board of the Institute of Molecular Pathology, Vienna Nature 494: 247-250 (2013), 40)           Sato, T., Clevers, H.. Review Hans Clevers obtained his MD degree in 1984 and his PhD degree in 1985 from the University Utrecht, the Netherlands. Cell 160: 299-312 (2015), 47)           Boj, S.F., Hwang, C.I., Baker, L.A., Chio, I.I., Engle, D.D., Corbo, V., Jager, M., Ponz-Sarvise, M., Tiriac, H., Spector, M.S., Gracanin, A., Oni, T., Yu, K.H., van Boxtel, R., Huch, M., Rivera, K.D., Wilson, J.P., Feigin, M.E., Öhlund, D., Handly-Santana, A., Ardito-Abraham, C.M., Ludwig, M., Elyada, E., Alagesan, B., Biffi, G., Yordanov, G.N., Delcuze, B., Creighton, B., Wright, K., Park, Y., Morsink, F.H., Molenaar, I.Q., Borel Rinkes, I.H., Cuppen, E., Hao, Y., Jin, Y., Nijman, I.J., Iacobuzio-Donahue, C., Leach, S.D., Pappin, D.J., Hammell, M., Klimstra, D.S., Basturk, O., Hruban RH, Offerhaus GJ, Vries RG, Clevers H, Tuveson DA. 19. From 1991-2002 Hans Clevers was Professor in Immunology at the University Utrecht and, since 2002, Professor in Molecular Genetics. So says Robert Vries, who has been working since 2013 to make HUB (Hubrecht Organoid Technology) the … h.clevers@hubrecht.eu. Cell Stem Cell 13: 653-658 (2013), 44)           Ritsma, L., Ellenbroek, S.I., Zomer, A., Snippert, H.J., de Sauvage, F.J., Simons, B.D., Clevers, H., van Rheenen, J. Intestinal crypt homeostasis revealed at single-stem-cell level by in vivo live imaging. In addition, the institute subsidizes open access publication via the golden route. Email: n.battich{at}hubrecht.eu (N.B. Nature 521: 43-47 (2015), 50)           Farin, H.F., Jordens, I., Mosa, M.H., Basak, O., Korving, J., Tauriello, D.V.F., de Punder, K., Angers, S., Peters, P.J. Oncode includes 62 research groups of the Dutch University Medical Centers, the Hubrecht Institute and the Netherlands Cancer Institute. 55)           Hu H., Gehart H., Artegiani B., Löpez-Iglesias C., Dekkers F., Basak O., van Es J., Chuva de Sousa Lopes S.M., Begthel H., Korving J., van den Born M., Zou C., Quirk C., Chiriboga L., Rice C.M., Ma S., Rios A., Peters P.J., de Jong Y.P., Clevers H. Long-term expansion of functional mouse and human hepatocytes as 3D organoids Review Nature Biotechnology, 37:303-313 (2019), 58)          Tuveson D, Clevers H. Cancer modeling meets human organoid technology. Prof. Dr. Edith Heard, EMBL, Heidelberg Technology is transferred to society as efficiently as possible. Culturing heart tissue. One of the main goals of the Hubrecht Institute is to build an interdisciplinary research institute that can tackle the most important problems in modern biology and medicine. 53)           Sachs N, de Ligt J, Kopper O, Gogola E, Bounova G, Weeber F, Balgobind AV, Wind K, Gracanin A, Begthel H, Korving J, van Boxtel R, Duarte AA, Lelieveld D, van Hoeck A, Ernst RF, Blokzijl F, Nijman IJ, Hoogstraat M, van de Ven M, Egan DA, Zinzalla V, Moll J, Boj SF, Voest EE, Wessels L, van Diest PJ, Rottenberg S, Vries RGJ, Cuppen E, Clevers H. A Living Biobank of Breast Cancer Organoids Captures Disease Heterogeneity. We were the first to link Wnt signaling with adult stem cell biology, when we showed that TCF4 gene disruption leads to the abolition of crypts of the small intestine (8), and that TCF1 gene knockout severely disables the stem cell compartment of the thymus (2). 2000               Member of the Royal Netherlands Academy of Sciences (KNAW) 10:123-132 (1991), 2)              Verbeek, J.S., Ison, D., Hofhuis, F., Robanus-Maandag, E., te Riele, H., van de Wetering, M., Oosterwegel, M., Wilson, A., MacDonald, H.R. Since 2008, the Hubrecht Institute is affiliated with University Medical Center Utrecht (UMC Utrecht), which belongs to the largest public healthcare institutions in the Netherlands and is an internationally leading healthcare provider, medical school and research institute that is exciting for its people, attractive to talent and embodies a culture of teamwork, innovation, sustainability and a competitive spirit. A breeding ground for spin off companies. Sort by citations Sort by year Sort by title. Utrecht Life Sciences is a platform that supports collaboration and innovation. 2016    The Körber European Science Prize, Germany Read More + Genetic overview. From Utrecht Central Station, it takes only 30 min to get to Amsterdam airport, Schiphol, an international hub for most major airlines. 2016 – present  Distinguished Visiting Professor, University of Hong Kong 2013 – 2015      Canada Gairdner Award, Toronto 2020 – present  Chair of the Scientific Advisory Board of Xilis, at Duke University (NC), Uppsalalaan 8 2012 – 2015      President of the Royal Netherlands Academy of Sciences (KNAW), Amsterdam 2012 – 2015      Member of the Board of the American Association of Cancer Research 2019               Honorary Fellow of the Royal Society of Edinburgh, Scotland, 2005 – 2015      Member Scientific Advisory Board of Swiss Institute for Experimental Cancer Research, Lausanne Publications 19. It promotes quality in science and scholarship and strives to ensure that Dutch scholars and scientists contribute to cultural, social and economic progress. The Princess Máxima Center has open her own new hospital and research building at the Utrecht Science Park in May 2018. Cell 136: 903-912 (2009), 27)           Sato, T., Vries, R., Snippert, H., van de Wetering, M., Barker, N., Stange, D., van Es, J., Abo, A., Kujala, P., Peters, P., and Clevers, H. Single lgr5 gut stem cells build crypt-villus structures in vitro without a stromal niche. Research groups. This has been a successful model in which the group leader has full scientific freedom and the organization can act decisively and flexibly. Nature 435: 959-963 (2005), 21)           Batlle, E., Bacani, J., Begthel, H., Jonkheer, S., Gregorieff, A., van de Born, M., Malats, N., Sancho, E., Boon, E., Pawson, T., Gallinger, S., Pals, S., Clevers, H. EphB activity suppresses colorectal cancer progression. The Hubrecht Institute is a research institute of the Royal Netherlands Academy of Arts and Sciences (KNAW), situated on Utrecht Science Park. Tumour suppressor RNF43 is a stem cell E3 ligase that induces endocytosis of Wnt receptors. The Hubrecht Institute is one of the fifteen outstanding national research institutes of the Royal Netherlands Academy of Arts and Sciences (KNAW). Cell 111: 251-263 (2002), 15)           Hurlstone, A.F., Haramis, A.P., Wienholds, E., Begthel, H., Korving, J., van Eeden, F., Cuppen, E., Zivkovic, D., Plasterk, R.H., Clevers, H. The Wnt/beta-catenin pathway regulates cardiac valve formation. Utrecht University is an international research university of the highest quality and the alma mater of many leading names, academics and scientists who have made an important contribution to the quality of society. Hubrecht Organoid Technology or HUB was founded around Organoid Technology. The Hubrecht Institute is a lively, international research community that is supported by high quality services. 2007 – 2010      Member of the National Scientific Advisory Board NKI-AVL, Amsterdam More than 10 years after the cultivation of the first organoid – at the Hubrecht Institute by Toshiro Sato in the group headed by Hans Clevers – the path to commercial applications is open. Since 2008, the Hubrecht is affiliated with the UMC Utrecht. He also serves as Director of the Princess Maxima Center for Pediatric Oncology. He also serves as Director of the Princess Maxima Center for Pediatric Oncology. Nature 556, 437-462 (2018). H Clevers. ↵ ‡ To whom correspondence should be addressed. Review. Nederland, © Copyright 2021 Privacypolicy Hubrecht Institute. Hans Clevers is group leader at the Hubrecht Institute and the Princess Máxima Center for Pediatric Oncology, professor of Molecular Genetics at the UMC Utrecht and Utrecht University, and Oncode Investigator. 2012               Member of the Royal Netherlands Society of Sciences and Humanities Prof. Dr. James Sharpe, EMBL, Barcelona Verbeek, J.S., Ison, D., Hofhuis, F., Robanus-Maandag, E., te Riele, H., van de Wetering, M., Oosterwegel, M., Wilson, A., MacDonald, H.R. 2009               Member of the Academia Europaea and Clevers, H. Depletion of epithelial stem cell compartments in the small intestine of mice lacking Tcf 4. The institute currently ranks as one of the top institutes worldwide in the field. 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