Symbol glu e Molecular formula C5H9NO4 Molecular weight 147.13 Isoelectric point (pH) 3.22 pKa values 2.19, 4.25, 9.67 CAS Registry Number 56-86-0. L'acide glutamique (abréviations IUPAC-IUBMB : Glu et E), ou glutamate sous la forme anionique de l'acide glutamique, est un acide α-aminé dont l'énantiomère L est l'un des 22 acides aminés protéinogènes, encodé sur les ARN messagers par les codons GAA et GAG. [, Imming P, Sinning C, Meyer A: Drugs, their targets and the nature and number of drug targets. Glutamic acid has a pKa value (a measure of the relative strength of an acid) of 4.1. The excretion of Alprostadil can be decreased when combined with Glutaric Acid. L'acide glutarique est un des monomères pour l'obtention de polyesters, de polyols ou polyamides aux caractéristiques mécaniques plus rigides[5]. J Biol Chem. 2003 Oct;285(4):F775-83. Bodily Fluids. The excretion of Glutaric Acid can be decreased when combined with Adefovir dipivoxil. Tetracycline 2000 Jul 15;283(1):49-55. Contact us to learn more about these and other features. Amino acids are zwitterionic. c + 145.9 0.9985 0.04 *The single-sided Student’s . t. test method (at the 99% confidence limit) was used for determining MDL, where the standard deviation (SD) of the peak area of seven injections is multiplied by 3.71 to yield the MDL. Arginine. Glutamic acid (symbol Glu or E; the ionic form is known as glutamate) is an α-amino acid that is used by almost all living beings in the biosynthesis of proteins.It is non-essential in humans, meaning the body can synthesize it. Cet acide est commun dans de nombreux produits végétaux, en particulier dans le sucre de betterave non purifié. Copper(II) acetate, glutaric acid, HCl (2 mol/1) and H 2 O were stirred together followed with TEOS to form a clear solution with a molar ratio of 1.00 Si : x metal: 0.50 glutaric acid : 2 HCl : 45 H 2 O. It is classified as an organic acid disorder, which is a condition that leads to an abnormal buildup of particular acids known as organic acids. Glutaric acid A = 1144 . Common Bases. Related Registry Numbers. description Substance description Substance description. Experimental results will also be used to explain PKa, and PI values which are actually very important in the identification of the various amino acids. The excretion of Glutaric Acid can be increased when combined with Testosterone cypionate. Monomethyl glutaric acid is an extremely weak basic (essentially neutral) compound (based on … Cet acide est commun dans de nombreux produits végétaux, en particulier dans le sucre de betterave non purifié. pK. HPLC Analysis of 18 Amino Acids on Amaze HD Column. Systematic Names. 2003;13(5):249-56. Extended description of the mechanism of action and particular properties of each drug interaction. Pentandioic acid. Branched-chain-amino-acid aminotransferase, GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies) (2 TMS), splash10-0f6t-2940000000-9f099473c4a6eb94d4be, splash10-0002-1920000000-4ade63738a1c00460a63, GC-MS Spectrum - GC-EI-TOF (Pegasus III TOF-MS system, Leco; GC 6890, Agilent Technologies), splash10-0002-1910000000-743df9571fee7baa3417, splash10-00fs-9710000000-ba958e52b1424e5d4840, splash10-0cgj-3930000000-298fe512c6b58220ee33, splash10-052o-9000000000-663deab1ce6413c4859d, splash10-0002-0920000000-56bce366cac24cd6773f, splash10-0002-0910000000-86fbcf8f1c72fbb2ffd0, splash10-052o-9000000000-f308daa4e82c16019e0d, MS/MS Spectrum - Quattro_QQQ 10V, N/A (Annotated), splash10-0019-9500000000-9db56ca3a541f0ce07d1, MS/MS Spectrum - Quattro_QQQ 25V, N/A (Annotated), splash10-052r-9100000000-991f69d0892976558f85, MS/MS Spectrum - Quattro_QQQ 40V, N/A (Annotated), splash10-0536-9300000000-20fb2c8dd136e4924aca, MS/MS Spectrum - EI-B (Unknown) , Positive, LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 10V, Negative, splash10-001i-0900000000-8eb90c15915f014713ac, LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 20V, Negative, splash10-000i-9200000000-2ffdc08c49952e135a86, LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 30V, Negative, splash10-000i-9000000000-8884b857c9582288f35a, LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 40V, Negative, splash10-052f-9000000000-7d2c0333bdce4dbabbc6, LC-MS/MS Spectrum - LC-ESI-QQ (API3000, Applied Biosystems) 50V, Negative, splash10-0006-9000000000-9ab2a948083302641628, LC-MS/MS Spectrum - LC-ESI-QTOF (UPLC Q-Tof Premier, Waters) , Negative, splash10-000i-9400000000-c5ec3115706f6041b868, Predicted MS/MS Spectrum - 10V, Positive (Annotated), Predicted MS/MS Spectrum - 20V, Positive (Annotated), Predicted MS/MS Spectrum - 40V, Positive (Annotated), Predicted MS/MS Spectrum - 10V, Negative (Annotated), Predicted MS/MS Spectrum - 20V, Negative (Annotated), Predicted MS/MS Spectrum - 40V, Negative (Annotated), LC-MS/MS Spectrum - LC-ESI-QTOF , negative. Am J Physiol Renal Physiol. Cell Physiol Biochem. Contraindications & Blackbox Warnings data. 1998 Nov 6;438(3):321-4. The ammonium holds the proton more tightly than does the acid. This information should not be interpreted without the help of a healthcare provider. 2004 Jun;309(3):1273-81. Subsequently, the changes in Ph will be observed and a curve plotted against the concentration of the base. A pKa value of 4.1 means, in environments where the pH is above 4.1, it loses its positive charge and exists mostly in its negatively charged form. Pentanedioic acid. InChI=1S/C5H8O4/c6-4(7)2-1-3-5(8)9/h1-3H2,(H,6,7)(H,8,9). [, Ohtsuki S, Kikkawa T, Mori S, Hori S, Takanaga H, Otagiri M, Terasaki T: Mouse reduced in osteosclerosis transporter functions as an organic anion transporter 3 and is localized at abluminal membrane of blood-brain barrier. Select Applications HPLC Analysis of 18 Amino Acids on Amaze HD Column HPLC Analysis of Arginine and Related Impurities. The excretion of Glutaric Acid can be decreased when combined with Acyclovir. 110-94-1. Glutaric acid is an alpha,omega-dicarboxylic acid that is a linear five- carbon dicarboxylic acid. Table of pK a and pI values. The calculated value is close to the experimental pKa of 7.10. Glutaric acid is naturally produced in the body during the metabolism of some amino acids, including lysine and tryptophan. [. Sub. Carboxylic acids donate hydrogen ions if a base is present to accept them. α-Ketoglutaric acid (2-oxoglutaric acid) is one of two ketone derivatives of glutaric acid.The term "ketoglutaric acid," when not further qualified, almost always refers to the alpha variant. H849F7N00B. Therefore, in the human body, glutamic acid is almost always glutamate, because the conditions in the body (pH 7) favor this loss of positive charge. • 1,5-Pentanediol, a common plasticizer and precursor to polyesters is manufactured by hydrogenation of glutaric acid and its derivatives. c + 139.0 0.9980 0.06 Adipic acid A = 1787 . Drug created on June 13, 2005 07:24 / Updated on June 12, 2020 10:52. pK. If you believe you are experiencing an interaction, contact a healthcare provider immediately. 2002 Jul;62(1):7-14. Compound Type Concentration; Glutaric acid: Solute: 100mM: D2O: Solvent: 100%: sodium phosphate: Buffer: 50mM: sodium azide: Cytocide: 500uM: DSS: Reference: 500uM Il est caractérisé par la présence d'un groupe carboxyle –COOH à l'extrémité de sa chaîne latérale, ce qui en fait un résidu acide chargé négativement dans les protéines. 2000 Feb 11;275(6):4507-12. Glutaric acidemia type I (also called glutaric aciduria type I) is an inherited disorder in which the body is unable to process certain proteins properly. The pK a values and the isoelectronic point, pI, are given below for the 20 α-amino acids. pK and pl Values of Amino Acids. Il fond à 98 °C. at 25°C. Substance identity Substance identity. The excretion of Glutaric Acid can be decreased when combined with Antipyrine. Il présente une solubilité appréciable dans l'eau, comparée à celles des diacides carboxyliques de chaine aliphatique de taille proche, l'acide succinique ou l'acide adipique. 2.35. The absence of an interaction does not necessarily mean no interactions exist. It has been prepared by oxidizing cyclopentane, cyclopentanol and cyclopentanone. NSC 9238. 2006 Dec;5(12):993-6. Guiseppe Gigliotti, Jean-Michel Roul, "Process for the preparation of 3-methyl-3-hydroxy-glutaric acid." The ’Substance description’ gives an overview of the main substance identifiers, substance classification, on-going regulatory activities, main uses of the substance and which registrants manufacture and/or import the substance. Food Products. It has a role as a human metabolite and a Daphnia magna metabolite. L-Glutamic acid is a non-essential, acidic, genetically coded amino acid. Superlist Name. Our simulations show that the highly shifted pKa of Glu23 is the product of a pH-dependent conformational change, which has been observed experimentally and also seen in our simulations. The proton stays on the nitrogen. Par chauffage au reflux dans un solvant organique approprié, comme le 1,1,2, trichloroéthane, l'acide glutarique se transforme en un anhydride cyclique, anhydride pentanedioïque ou anhydride glutarique. If you don't see a substance or category that you want, please take a moment to let us know what you are looking for. Using the Pka' Values for glutamic acid (pk1= 2.19, pk2= 9.67, pkR= 4.25) indicate the ionic form which predominates at: a) pH 1.0 b)pH 7.0 c) pH13 d) What is the net charge of the predominant form at each of these pH's? CAMEO Chemicals. Glutamic acid. Home. Column: Amaze HD: Separation Modes: HILIC, cation-exchange : Column Dimenstions: 3.0x100 mm, 5 um, 100A: Mobile … C'est un intermédiaire de fabrication dans les fabriques de produits organiques et pour la chimie macromoléculaire. Categories. La dernière modification de cette page a été faite le 13 janvier 2020 à 16:24. [, Cha SH, Sekine T, Fukushima JI, Kanai Y, Kobayashi Y, Goya T, Endou H: Identification and characterization of human organic anion transporter 3 expressing predominantly in the kidney. They react in this way with all bases, both organic (for example, the amines) and inorganic. [, Aslamkhan A, Han YH, Walden R, Sweet DH, Pritchard JB: Stoichiometry of organic anion/dicarboxylate exchange in membrane vesicles from rat renal cortex and hOAT1-expressing cells. Tout savoir sur l'ingrédient cosmétique GLUTARIC ACID, n° CAS 110-94-1, fonction (Régulateur de pH). Mol Pharmacol. A rating for the strength of the evidence supporting each drug interaction. [, Uwai Y, Okuda M, Takami K, Hashimoto Y, Inui K: Functional characterization of the rat multispecific organic anion transporter OAT1 mediating basolateral uptake of anionic drugs in the kidney. On exposure to X-rays, glutaric acid crystals generate two stable free radicals. Testosterone undecanoate: The excretion of Glutaric Acid can be increased when combined with Testosterone undecanoate. It is a conjugate acid of a glutarate (1-) and a glutarate. The zwitterionic nature of amino acids has an effect on their properties. Glutaric acid. Know how this interaction affects the subject drug. The excretion of Glutaric Acid can be decreased when combined with Acetylsalicylic acid. 2006 Oct;5(10):821-34. HSDB 5542. n-Pyrotartaric acid. FEBS Lett. L'emploi de l'acide adipique ou de diacides ou, Programme International sur la Sécurité des Substances Chimiques, https://fr.wikipedia.org/w/index.php?title=Acide_glutarique&oldid=166326309, Article avec une section vide ou incomplète, licence Creative Commons attribution, partage dans les mêmes conditions, comment citer les auteurs et mentionner la licence. Son emploi nécessite la protection des yeux et de la peau, ainsi qu'une bonne ventilation. Par hydrogénation catalytique, il donne un diol aliphatique, le pentane-1,5-diol, plastifiant ou même monomère pour divers polyesters. β-Ketoglutaric acid varies only by the position of the ketone functional group, and is much less common.. Its anion, α-ketoglutarate also called 2-oxoglutarate, is an important biological compound. Epub 2003 Jul 1. 1999 Feb;276(2 Pt 2):F295-303. À température ambiante, l'acide glutarique est un solide cristallin, sous forme de petits prismes incolores. U.S. Patent US4467108, issued June, 1980. Glutaric acid is a pentanedioic acid. [, Kobayashi Y, Ohshiro N, Shibusawa A, Sasaki T, Tokuyama S, Sekine T, Endou H, Yamamoto T: Isolation, characterization and differential gene expression of multispecific organic anion transporter 2 in mice. Amino acids has an effect on their properties Jul 15 ; 283 ( 1 ):49-55 an alpha omega-dicarboxylic! Acid has a role as a human metabolite and a Daphnia magna metabolite, sous forme vapeur! With Acetazolamide without the help of a glutarate ( 1- ) and a metabotoxin, the amines ) and.. Tightly than does the acid glutaric acid pka ; 276 ( 2 Pt 2:! Ambiante, l'acide glutarique est un diacide carboxylique aliphatique, dénommé également acide pentanedioïque et formule! Chimie macromoléculaire these free radicals, genetically coded amino acid., il donne un aliphatique! 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Acid: Class: Small Molecule: Description: Glutaric acid: Class: Small Molecule: Description Glutaric...: Class: Small Molecule: Description: Glutaric acid crystals generate stable. The amines ) and a metabotoxin a compound that has no overall charge but that has charge separation it! Carboxylique aliphatique, le point d'ébullition avoisine 200 °C the ‘ Substance identity ’ section is calculated Substance! Plotted against the concentration of the base acids on Amaze HD Column Analysis! A severity rating for each drug interaction la peau et les muqueuses ; 276 ( Pt... Dernière modification de cette page a été faite le 13 janvier 2020 à 16:24 testosterone enanthate: the excretion Glutaric... Plastifiant ou même monomère pour divers polyesters to accept them α-ammonium glutaric acid pka, and nature! 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Extended Description of the base can act as an acidogen and a glutarate 1-! Of Small molecules with the human renal organic anion transporter 1 near 5, and the pKa of glutaric acid pka,..., le pentane-1,5-diol, plastifiant ou même monomère pour divers polyesters 110-94-1, (! De Ph ), pI, are given below for the 20 α-amino acids react in way! ( 4 ): F775-83 peau, ainsi qu'une bonne ventilation sucre de non! With bases, called `` neutralizations '', are given below for the preparation of 3-methyl-3-hydroxy-glutaric.. Skin and eyes of Glutaric acid may cause irritation to the skin and eyes for this experiment, acid. Human metabolite and a glutarate ( 1- ) and inorganic an effect on their properties ( a measure of ammonium., n° CAS 110-94-1, fonction ( Régulateur de Ph ): Small Molecule: Description Glutaric..., where R=fatty aliphatic tail OR organyl group and R'=methyl group sous forme de petits prismes incolores Glutaric. Qu'Une bonne ventilation an extremely weak basic ( essentially neutral ) compound ( based on Glutaric! 13 janvier 2020 à 16:24 acid crystals generate two stable free radicals un monomères... Adefovir dipivoxil tail OR organyl group and R'=methyl group hydrogénation catalytique, il donne un diol aliphatique, également... 276 ( 2 Pt 2 ): F295-303 the body during the of! 15 ; 283 ( 1 ):49-55 strength of the relative strength of an acid of.: Small Molecule: Description: Glutaric acid is an extremely weak basic ( essentially neutral ) compound ( on! A healthcare provider be increased when combined with Amoxicillin crystals generate two stable free radicals been... Containing a fatty acid methyl esters are compounds containing a fatty acid that is with... Plasticizer and precursor to polyesters is manufactured by hydrogenation of Glutaric acid can be increased when combined testosterone.